The study found a significant association between metabolic syndrome (MetS) and an increased risk for gastrointestinal (GI) cancers. MetS and its components were linked to a higher risk for colorectal, esophageal, gallbladder, liver, and pancreatic cancers. Lifestyle changes or medical interventions targeting MetS patients could be potential prevention strategies for GI cancers. MetS components like hypertension, low HDL-C, hypertriglyceridemia, hyperglycemia were associated with specific GI cancers. Mendelian randomization analyses showed causal associations between certain traits and GI cancers in European and Asian populations. The study highlighted the potential for preventing GI cancers through addressing MetS.
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Metabolic Syndrome Associated With Risk for Various GI Cancers
