What to Know About Treatment-Resistant Depression

Standard treatments help most people with depression, but about 30% continue to have severe symptoms after trying multiple antidepressants, known as treatment-resistant depression. For those affected, it’s important not to give up as there are still management options available. Experts do not have one definition for treatment-resistant depression, but it generally occurs when two different antidepressants fail to work. Options for managing treatment-resistant depression include adjunctive medication, talk therapy like cognitive behavioral therapy, ketamine, and brain stimulation. It is crucial to work closely with a psychiatrist to explore all available treatment choices and not settle for partial improvement.

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