Exposure to acid-suppressive medications in infants increases the risk of developing food allergies, anaphylaxis, atopic dermatitis, and allergic rhinitis. Proton pump inhibitors present the highest risks, with risk ratios ranging from 2.17 to 11.23. Researchers hypothesize that these medications may increase allergy risks by causing gut dysbiosis. The study, which included 56,492 patients prescribed PPIs before age 1, calls for further research on the mechanisms underlying these findings. Physicians should consider these risks when prescribing acid-suppressive medications and discuss potential alternatives with patients.
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Acid-suppressive medications in infancy associated with food allergy risks
