Fractional Flow Reserve-Guided PCI Cost-Effective

Fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) for non-infarct-related arteries (IRAs) in patients with acute myocardial infarction (AMI) and multivessel disease was found to be more cost-effective and improved quality of life compared to angiography-guided PCI. A prespecified analysis of the FRAME-AMI trial showed that FFR-guided PCI increased quality-adjusted life years by 0.06 and reduced total cumulative costs per patient by $1208. The incremental cost-effectiveness ratio and incremental net monetary benefit favored FFR-guided PCI. The authors recommended considering FFR-guided PCI for non-IRA stenoses in these patients, noting its potential to achieve complete revascularization and combat rising costs in AMI. Funding was received from various sources, including Medtronic and Biotronik.

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