A recent study found that a cell-free DNA blood test aimed at detecting abnormal DNA signals in people with an average risk of colorectal cancer (CRC) was successful in detecting most cases of CRC in confirmed patients. The blood test had a sensitivity of 83% for CRC and 90% specificity for advanced neoplasia, but only a 13% sensitivity for advanced precancerous lesions. Despite its promising results, the accuracy of the blood test is lower compared to colonoscopy, which remains the gold standard for CRC screening. Future research is needed to determine the optimal role and implementation of blood-based tests for CRC screening.
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