Scientists discover a key mechanism used by human herpesvirus 8 to induce cancer

Cleveland Clinic researchers have discovered how Kaposi’s sarcoma-associated herpesvirus (KSHV) induces cancer by manipulating human enzymes CDK6 and CAD. This finding has significant implications as viruses cause 10-20% of cancers globally. The study showed that inhibiting the virus’s manipulation of these enzymes with existing drugs could reduce replication, block progression, and shrink tumors in preclinical models. Understanding this mechanism could lead to new treatment options for KSHV-associated cancers. Researchers aim to apply this knowledge to other cancer-associated viruses. By uncovering vulnerabilities in virus-induced cancers, they hope to develop more effective treatments and potentially prevent cancer formation in the future.

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