Rare condition post-orgasmic illness syndrome explored in depth

Researchers reviewed existing studies on post-orgasmic illness syndrome (POIS), a rare condition with limited knowledge. Symptoms include nasal congestion, fatigue, and itchiness following ejaculation, with onset within minutes and lasting up to seven days. Primary POIS occurs during puberty, while secondary develops later. Diagnosis requires specific symptom clusters and timing. Causes may involve immune hypersensitivity, hormonal imbalance, or autonomic nervous system dysregulation. Treatments include SSRIs, antihistamines, and alpha-blockers. Surgical options have shown some relief. Although rare, POIS affects mental well-being and relationships. Further research may lead to better diagnostics and management strategies for this challenging condition.

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