New “GPS nanoparticle” delivers a genetic punch to the protein implicated in tumor spread

Researchers developed a “GPS nanoparticle” that targets cancer cells to deliver a genetic punch, potentially treating basal-like breast cancers more effectively. This technology, published in ACS Nano, uses a Trojan horse nanoparticle disguised with special lipids carrying CRISPR-Cas9 molecules to target and knock down cancer-causing genes. The nanoparticles are designed to respond in the low pH environment of cancer cells and attach to specific markers on cancer cells. This approach reduces off-target delivery and immune system responses. The team plans to test this platform further for potential clinical applications and explore other ways to use this technology for healing in different areas.

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