More Severe AKI Predicts Adverse Outcomes in Critically Ill Children

Two new studies published in JAMA Network Open show that both recurrent and severe acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) in children lead to worse outcomes. Infants with recurrent AKI have longer hospital stays compared to those with a single episode. Risk factors for recurrent AKI include younger gestational age, lower birthweight, and higher initial AKI stage. Another study found that CKRT for AKI or fluid overload in children often leads to major adverse kidney outcomes. A new device has been approved by the FDA to improve pediatric AKI outcomes by selectively targeting proinflammatory cells during CKRT.

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