This article discusses the evolving treatment trajectories for patients with incurable solid cancers, focusing on the impact of newer systemic anticancer treatments, such as immunotherapy and targeted therapy. The updated trajectories now include major temporary improvement, long term ongoing response, rapid decline due to adverse events, and the traditional trajectory. The importance of discussing patients’ goals and preferences, along with providing supportive and palliative care, is emphasized throughout the article. Challenges, such as psychological, social, and physical issues, as well as the need for more patient-centered care and early supportive interventions, are also highlighted. Patient involvement in the creation of the article was noted, and future research questions were proposed.
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Illness trajectories of incurable solid cancers
