Brexpiprazole is Efficacious in Reducing Alzheimer Dementia-Related Agitation

Treatment with brexpiprazole has shown significant reductions in agitation among patients with dementia due to Alzheimer’s Disease. Agitation is difficult to manage and often indicates disease progression. Brexpiprazole was evaluated in two 12-week trials and showed improvement in agitation and psychosis symptoms compared to placebo. The drug was found to be effective regardless of dementia severity or other symptoms. Brexpiprazole was also found to be more effective than other drugs like risperidone, memantine, and haloperidol in reducing agitation. While the drug was generally well-tolerated, there were a higher number of deaths among patients with baseline psychosis taking brexpiprazole.

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