Is there an association between vitamin D, immunocompetence, and aging?

Researchers conducted a review on the role of vitamin D in immunocompetence and how it is affected by aging. Vitamin D influences bone health and immunity, and its deficiency affects the production of active vitamin D metabolites. Vitamin D responsiveness varies among individuals due to genetic and epigenetic factors. Vitamin D influences gene expression and has epigenomic effects, affecting the immune system. It may preserve immunocompetence and protect against diseases, including cancer. To strengthen immunocompetence, personalized vitamin D supplementation is suggested, considering individual responsiveness. This could help guard against prevalent diseases and promote healthy aging.

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