Mortality Risk for Antipsychotics Is Dose-Dependent Among Children, Young Adults

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A study published in JAMA Psychiatry found that children aged 5 to 17 who received up to 100-mg chlorpromazine equivalents of antipsychotic medication did not face an increased risk of mortality. However, young adults aged 18 to 24 who received doses over 100 mg faced a significantly elevated risk for death. The study included over 2 million Medicaid patients and found that high doses of antipsychotic medications increased the risk for overdose and unintentional injury deaths in young adults, but not in children. The study authors emphasized the need for further research to better understand the increased risk of death with higher doses in young adults.

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