Researchers found that almost one in five patients diagnosed with multisystem inflammatory syndrome in children (MIS-C) using the 2020 definition would not be diagnosed using the updated 2023 definition. The syndrome is associated with SARS-CoV-2 and usually occurs 2 to 6 weeks after a child is infected. The new definition no longer requires the presence of fever and other biomarkers but does require C-reactive protein (CRP) of 3 mg/dL or more to indicate systemic inflammation, among other changes. Another study found that children diagnosed with MIS-C suffered significant, persistent microvascular damage with redistribution of the vessel architecture, suggesting a long-term association with arterial stiffness.
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Many patients diagnosed with MIS-C do not fit updated definition
