Familial SCAD linked to aggregation of common genetic variants

Research has shown that high concentrations of common genetic variants within families are associated with an increased inherited risk for spontaneous coronary artery dissection (SCAD). Rarer genes associated with inherited connective tissue disorders were not found to be associated with SCAD risk. The study was based on a cohort of 1,352 genotyped individuals, including healthy controls, sporadic SCAD cases, and families with SCAD. The study also highlights the role of polygenic risk score (PRS) in predicting SCAD risk. The implications of the study are that identifying family members at risk of experiencing SCAD is the first step towards implementing preventive approaches.

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