COVID-19-associated blood plasma inflammatory factors do not affect blood-brain barrier, study shows

The coronavirus outbreak has resulted in a global health crisis, prompting researchers to investigate the potential impact of blood-brain barrier impairment on neurological problems during COVID-19 progression. The blood-brain barrier is a filtering mechanism for blood vessels carrying blood to the brain and spinal cord, preventing the passage of certain toxic substances. The study found that COVID-19-associated blood plasma inflammatory factors do not directly affect the blood-brain barrier pathway, suggesting that any pathological remodeling during COVID-19 may occur through indirect or unknown mechanisms. The research team emphasized the importance of understanding the connection between blood cytokine/chemokine profiles, blood-brain barrier integrity, and the severity of neurological symptoms in COVID-19 patients.

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