A study of 242,779 participants found that men have a 1.6-fold increased risk for colorectal cancer and reach equivalent risk 6 years earlier than women. This was determined by using a risk-advancement period approach, based on sex and polygenic risk score criteria. It was found that the polygenic risk score was strongly related to colorectal cancer risk in a dose-response manner. Researchers observed similar associations between colorectal cancer mortality and corresponding risk-advancement periods. The study suggests that personalized starting ages of colorectal cancer screening would vary by as much as 24 years between men with a high genetic risk score and women with a low genetic risk score. Hermann Brenner and colleagues conducted this study.
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Model identifies 24-year difference in recommended CRC screening age between men, women
