Researchers led by Dr. Shuyang Yu, Dr. Jingyu Xu, and Dr. Xuguang Du from China Agricultural University and Zunyi Medical University studied the role of Mettl3 in CD8 T cell response during acute infection. They found that m6A modifications play a key role in regulating the CD8 T cell response. Mettl3-deficient CD8 T cells showed decreased proliferation and increased apoptosis, resulting in defective clonal expansion. The study also revealed that Mettl3-mediated m6A modification regulates cell cycle- and differentiation-related genes’ expression, including binding to the Tbx21 transcript to sustain stability and normal production of T-bet protein. Overall, the study illustrates the essential role of Mettl3 in regulating CD8 T cell response during acute infection.
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Mettl3 guides CD8 T cells to eliminate infected cells with maximum efficiency
