A study led by researchers at Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center, and Korea’s Yonsei University found that DNA secreted by tumor cells in extracellular vesicles can trigger an immune response that inhibits the spread of tumors to the liver. The findings suggest a new understanding of cancer progression and anti-cancer immunity, with potential clinical applications in assessing and reducing metastasis risk. The study discovered that EV-DNA acts as a danger signal, activating an anti-tumor response in the liver. The researchers hope to develop a prognostic test for metastasis risk and a therapy to enhance tumor EV-DNA signaling to suppress metastasis.
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Tumor secreted DNA triggers immune response against liver metastasis Special…
