Study reveals novel approach to promote efficient uptake of ASOs into cancer cells

Antisense oligonucleotides (ASOs) are promising next-generation drugs that can block harmful messages from genes, potentially treating diseases like cancer. However, delivering ASOs into cancer cells has been a major challenge as the cells have gatekeeper molecules that prevent their entry. Researchers at Osaka University have developed a new compound called L687, which opens specific calcium…

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How New Ideas Are Changing Advanced Breast Cancer Research

Dr. Lisa Newman highlights reasons for hope for women with advanced breast cancer, including improving treatments and targeted therapies with fewer side effects. Research on circulating cancer cells and precision medicine is promising. However, African American women face higher death rates due to systemic racism affecting healthcare access and delays in diagnosis. More research is…

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First Long-Term Data on Atogepant for Migraine Prevention

An ongoing extension study supports the long-term safety and efficacy of the oral CGRP receptor antagonist atogepant in preventing chronic and episodic migraine. 70% of patients treated with atogepant achieved at least a 50% reduction in monthly migraine days at 13-16 weeks, maintained over 48 weeks. The study, reported at the American Academy of Neurology…

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Know All About Deadly Infection

A 37-year-old man in Hong Kong tested positive for the rare human B virus after being attacked by a wild monkey. The virus can lead to severe brain damage or death and can be transmitted through bites, scratches, or contact with saliva, feces, urine, or tissue from infected monkeys. Symptoms of infection include flu-like symptoms,…

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EConsent Workflows Must Evolve to Support Interoperability and Health Equity

A webinar on April 16 at 1pm ET will discuss how healthcare organizations and health tech companies can collaborate to improve interoperability through eConsent, moderated by Aneesh Chopra. The panel, including representatives from DocuSign and Velatura, will focus on streamlining patient consent for sharing protected health information (PHI), complying with regulations, and improving care coordination….

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Government approves further expansion of role of pharmacists 

The Cabinet has approved new legislative amendments to expand pharmacists’ responsibilities, including the ability to prescribe. The Expert Taskforce on Pharmacy in Ireland has been reviewing the role of pharmacists in primary care and has made recommendations for changes. Health Minister Stephen Donnelly has secured approval for an amendment to the Health (Miscellaneous Provisions) Bill…

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Standards of Care encourages more people with diabetes to use CGM

The 2024 ADA Standards of Care recommend continuous glucose monitoring (CGM) for all people with type 1 diabetes. CGM, along with certain insulins, can help people recognize, prevent, and treat hypoglycemia. Joanne Rinker, a board-certified advanced diabetes manager, highlighted these changes at a conference. Providers are encouraged to offer CGM to all adults on insulin,…

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Intra-Cellular reports positive results in depression study

Intra-Cellular Therapies announced positive results from a Phase 3 clinical trial for its antipsychotic medicine Caplyta in treating major depressive disorder. The study showed a significant reduction in depressive symptoms compared to a placebo on the MADRS scale. The drug also demonstrated benefits on a patient-reported measure of depression severity. Common side effects included dry…

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