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Biotech veterans launch Corsera, a new heart disease startup with lofty goals

Allison DeAngelis , 2025-09-02 10:30:00

Allison DeAngelis is the East Coast biotech and venture capital reporter at STAT, reporting where scientific ideas and money meet. She is also co-host of the weekly biotech podcast, The Readout Loud. You can reach Allison on Signal at AllisonDeAngelis.01.

Biotech veterans John Maraganore and Clive Meanwell have had a hand in multiple paradigm-shifting medicines over the last three decades. But on Tuesday, the duo launched a new venture they say may be their most important work to date.

The venture, Corsera Health, is a small company with a big goal: Create a world without cardiovascular disease. Corsera is developing an AI tool called Klotho Health that will predict a person’s likelihood of developing cardiovascular disease. In tandem with that effort, Corsera is working on an RNAi drug that targets PCSK9 — one of the known drivers of heart disease — and angiotensinogen, which influences blood pressure. 

The company plans to start a clinical trial of that drug by the end of the year.

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