A study by deCODE Genetics found that sequence variants drive the correlation between DNA methylation and gene expression, which are also linked to diseases and human traits. Nanopore sequencing technology allows for real-time analysis of DNA sequences, including DNA methylation, providing opportunities to understand how noncoding variants lead to diseases. The study shows that sequence variants affect DNA methylation and gene expression, with many disease-linked variants found in the noncoding genome. By analyzing the effects on DNA methylation, scientists can better understand how these variants contribute to disease progression. The research was published in Nature Genetics.
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Study links sequence variants to DNA methylation and diseases
