A study conducted by a research team at the University of Konstanz, led by toxicologist Ivano Amelio, has shown that different mutations of the tumor suppressor p53 have varying effects on pancreatic carcinomas. The p53 protein plays a crucial role in inhibiting cell proliferation and promoting cell death in case of DNA damage, but mutations in p53 can lead to uncontrolled cell growth and tumor formation. The research team found that different p53 mutations affect metabolic pathways differently in pancreatic carcinomas, leading to new insights in cancer research. This emphasizes the importance of studying individual mutation variants of p53 to better understand and counteract tumor development.
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p53 mutations show diverse impact on pancreatic cancer metabolism
