In orthopedic medicine, managing infected bone defects (IBDs) is a major challenge. Advanced biomaterials have led to the development of a dual-functional bone regeneration scaffold, Qx-D, capable of promoting bone growth and fighting infections. This scaffold, created by modifying demineralized bone matrix with a macromolecular quaternary ammonium salt, demonstrated excellent antibacterial properties against various bacteria strains. In addition to its antimicrobial effects, Qx-D showed good biocompatibility and supported bone marrow stromal cell differentiation. In a rat model, Qx-D reduced inflammation and promoted bone regeneration, suggesting its potential as a standard-of-care option for treating infected bone defects.
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Dual-functional Qx-D scaffolds hold immense promise for treating infected bone defects
