Scientists are exploring the potential of repurposing the anti-malarial drug hydroxychloroquine to fight cancer, despite disappointing clinical trial results. Research from the Medical University of South Carolina’s Hollings Cancer Center found that cancer cells develop resistance to hydroxychloroquine not through expected pathways, but by changes in metabolism, division, and export. This discovery opens the door to new combination treatments targeting these resistance mechanisms. Repurposing old drugs like hydroxychloroquine offers promise in fighting cancer by targeting multiple pathways, making it harder for cancer cells to develop resistance. Understanding these mechanisms can lead to more effective cancer treatments.
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Exploring the cancer-fighting promise and limitations of hydroxychloroquine
