A study presented at the American Heart Association Scientific Sessions in November 2024 found that three different dual-medication polypills effectively lowered blood pressure for Indian adults with hypertension. The study, called TOPSPIN, included 1,981 participants and showed that all three combinations of antihypertensive drugs were equally effective in lowering blood pressure. The researchers found no significant differences in blood pressure lowering between the three different combinations. The study also highlighted the importance of combination therapy for hypertension treatment, as patients treated with combination therapy are more likely to be adherent to therapy and persistent with treatment.
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