A recent analysis found that receiving radiotherapy after prostatectomy negatively affects long-term health-related quality of life, including sexual function, urinary incontinence, and urinary irritation. However, the timing of radiation after surgery, whether within a year or over a year, does not have a significant impact on patients’ quality of life over the long term. Delaying radiotherapy after surgery can help avoid overtreatment and mitigate toxic effects. Patients who received early radiation initially experienced worse urinary incontinence and sexual health but showed more pronounced recovery in the long term compared to those who received late radiation. Overall, early radiation may be considered for high-risk patients.
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