A Ludwig Cancer Research study discovered a metabolic switch in T cells crucial for creating memory T cells, providing lasting immunity to known pathogens and improving anticancer immune responses. This study identified PPARβ/δ as the master regulator of this switch. Furthermore, TCF1, a protein in T cells, activates this pathway, promoting the formation and maintenance of TCMs and progenitor-exhausted T cells that can fight cancer. Pharmacologically engaging this switch could enhance cancer immunotherapies. By investigating the therapeutic potential of targeting PPARβ/δ signaling in mice with melanoma, the researchers found improved anti-tumor responses. Further research in people is needed to explore this potential.
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Study reveals metabolic switch crucial for memory T cell formation and cancer immunity
