Researchers at the Center for Genomic Regulation (CRG) have discovered that adding interferon gamma (IFNγ) can accelerate the reprogramming of induced pluripotent stem cells (iPSCs) in mice by one day, saving time and resources. This treatment enhances the production and quality of pluripotent stem cells, which are valuable in disease modeling and drug testing, especially for individuals with two X chromosomes. IFNγ has been found to reactivate the X chromosome more efficiently, leading to high-quality iPSCs. This discovery has the potential to improve personalized medicine for women and ensure the success of experimental therapies. The research is published in the journal Science Advances.
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Study finds viral defense protein speeds up female stem cell production
