An observational study ranked eight commonly used antidepressants based on their potential to cause weight gain. Bupropion was associated with the lowest weight gain, while escitalopram, paroxetine, and duloxetine were linked to the greatest weight gain. Users of escitalopram, paroxetine, and duloxetine were more likely to gain at least 5% of their baseline weight compared to those taking sertraline. The study, published in the Annals of Internal Medicine, analyzed data from 183,118 adults using electronic health records from 2010 to 2019. The findings aim to provide clinicians and patients with real-world evidence to make informed decisions about choosing antidepressants based on weight gain potential.
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Eight Common Antidepressants Ranked by Weight Gain Potential
