TLS are lymphoid structures found in inflamed salivary glands in patients with Sjögren’s disease, associated with increased disease activity, autoantibody production, and malignancy risk. A study by Saba Nayar focused on mapping different cell types and populations within these structures to better understand the salivary gland microenvironment. Another study by Loïc Meudec looked at developing and characterizing organoids of salivary gland epithelial cells (SGEC) to study their pathogenic role in Sjögren’s disease. These organoids showed potential for long-term culture and differentiation, with implications for drug development targeting the underlying pathogenesis of the disease. Understanding the cellular landscape of the salivary gland may lead to new therapeutic discoveries in the future.
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Understanding salivary gland microenvironment to advance Sjögren’s disease treatment
