A study presented at the American Headache Society Annual Scientific Meeting found that patients with migraine who received daytime psilocybin experienced reduced REM sleep, with effects lasting beyond the day of administration. The study included eight adults with migraine who participated in two drug administration sessions, receiving either psilocybin or diphenhydramine. Results showed that psilocybin led to reduced percentage of REM sleep compared to baseline and diphenhydramine, with effects lasting beyond the night of administration. The study was funded by the Wallace Research Foundation and aimed to explore the potential therapeutic effects of psilocybin on migraine.
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Daytime psilocybin adversely affects REM sleep in those with migraine
