Research offers first insights into the mechanism behind synaptic development

A recent study from Kobe University analyzed how synaptic proteins change during early development in mice and marmosets, as well as individuals with autism spectrum disorders. This research provides insights into the mechanism behind synaptic development and potential treatments. Primate brains undergo a process of synaptic pruning after early childhood, reducing connections between brain cells. However, little is known about the molecular mechanisms involved in synapse maturation, hindering progress in treating neuropsychological disorders such as autism. By analyzing protein changes in the postsynaptic density, the researchers identified differences in gene regulation and timing of protein changes between mice and marmosets, shedding light on the molecular basis of synaptic development and neuropsychological disorders.

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