Alzheimer’s Transmissible Via Stem Cell Transplantation?

A study in preclinical models suggests that familial Alzheimer’s disease (AD) may be transmissible via bone marrow transplant, but experts warn against immediate conclusions for humans. Researchers found that transplanting mutant amyloid precursor protein (APP) stem cells into mice resulted in rapid development of AD-like symptoms. While this finding raises concerns about disease transmission through blood, tissue, and stem cell donors, experts believe the risk is low due to the rarity of familial AD and safeguards in transplantation procedures. They caution against extrapolating these findings to human organ or blood transfusions. The study’s relevance to human transplantation is limited, but it does provide insights for potential new biomarkers for AD.

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