Men with Klinefelter syndrome, a genetic condition affecting fertility in one out of every 600 men, face infertility due to an extra X chromosome. Professor Qiao Jie’s research at Peking University reveals that this extra chromosome causes disrupted gene activity and movement in fetal germ cells, leading to early loss of key reproductive cells. By studying these cells, the team identified potential treatments using TGF-β inhibitors to help the cells mature normally. This research offers new insights into the molecular mechanisms of infertility in men with Klinefelter syndrome, providing hope for those struggling to become fathers.
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New insights into Klinefelter syndrome and male infertility
