Scientists at Korea University have developed a new technique to reprogram fibroblast cells into mature and functional induced cardiomyocytes (iCMs) by combining fibroblast growth factor 4 (FGF4) with vitamin C. This approach activates the JAK2–STAT3 signaling pathway, leading to improved cell structure and function. The findings offer promising possibilities for regenerative medicine in treating cardiovascular diseases, which are a leading cause of death worldwide. While further studies are needed to ensure safety and effectiveness, this method could potentially revolutionize treatments for heart conditions by using a patient’s own cells to repair damaged tissue, reducing reliance on heart transplants.
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New method transforms ordinary fibroblasts into mature cardiomyocytes
