The Horner–Wadsworth–Emmons (HWE) reaction is crucial in organic chemistry for creating conjugated carbonyl compounds used in various industries. Improving HWE reactions is a focus of research, with potential applications in developing anti-cancer compounds. Tokyo University of Science researchers have developed a highly selective HWE reaction method using a magnesium phosphonoenolate intermediate, allowing for isolated active species and broad substrate scope. This breakthrough offers a faster and more versatile approach than traditional methods, showing promise for synthesizing pharmacologically active compounds. The team’s study enhances understanding of the reaction mechanism and highlights potential for developing novel anti-cancer drugs.
Source link
Breakthrough in HWE reaction offers pathway for anti-cancer drug development
