Researchers led by the Hubrecht Institute and Roche’s Institute of Human Biology have developed strategies to identify regulators of intestinal hormone secretion. These hormones play key roles in digestion and appetite. By studying rare enteroendocrine cells (EECs) in the gut, the team identified new tools to explore potential ‘nutrient sensors’ on these cells and how they function. This research could lead to new ways to interfere with hormone release and treat metabolic or gut motility disorders. Using organoids, researchers isolated human EECs and identified sensory receptors that control hormone secretion, offering new insights into how the body responds to food triggers.
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Researchers develop strategies to identify regulators of intestinal hormone secretion
