Researchers at the University of Dundee have made significant progress in understanding the mechanisms of protein degraders, which can target diseases previously deemed untreatable. More than 50 drugs of this kind are in clinical trials, offering hope to patients with limited options. Utilizing cryo-electron microscopy, researchers were able to visualize how protein degraders interact with disease-causing proteins at the molecular level. By identifying key areas for tagging disease-causing proteins with ubiquitin, the effectiveness of degradation is maximized. This breakthrough research sheds light on a new approach to drug discovery and treatment of challenging diseases, representing a significant advancement in the field.
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New insights on protein degraders open doors to treatment for ‘undruggable’ diseases
