Scientists discover a new understanding of how an old hormone works, paving way for better therapies

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Researchers at Monash University have made a breakthrough in understanding how the hormone peptide glucagon works, potentially leading to improved treatments for obesity and type 2 diabetes. Glucagon, like insulin, helps regulate blood sugar levels, but its mechanisms were not fully understood until now. The study, published in Nature Communications, revealed how glucagon signals within cells and the liver, identifying a key protein called SEC22B involved in its metabolic actions. This discovery may pave the way for more effective therapies for metabolic diseases and provide new insights into developing treatments for conditions like obesity and type 2 diabetes.

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