Researchers developed lab-grown intestines to study Crohn’s disease, identifying two molecular subtypes – immune-deficient infectious type (IDICD) and stress-induced fibrostenotic type (S2FCD). These subtypes show distinct characteristics and respond differently to treatments. The study used patient-derived organoids (PDOs) to analyze genetic and phenotypic features of CD. The research, published in Cell Reports Medicine, aimed to improve personalized therapeutics for CD patients. Individualized treatments were shown to be effective for specific subtypes, highlighting the importance of understanding CD heterogeneity to develop tailored therapies. PDOs provide a promising tool to study and develop treatments for various CD subtypes.
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Scientists uncover two Crohn’s disease subtypes using lab-grown intestines, offering hope for personalized therapies
