Experts are recommending the use of single-pill combinations containing three or four antihypertensive medications for managing patients with elevated blood pressure. This approach involves starting with low doses of a triple combination pill that includes telmisartan, amlodipine, and indapamide. Studies have shown that this method effectively lowers blood pressure and improves control. The VERONICA trial in Nigeria demonstrated significant reductions in blood pressure and improved control when using this approach. A separate study, QUADRO, found that a four-drug combination pill was more effective in treating resistant hypertension than a triple combination. Adherence and reducing pill burden are key factors in the success of these combination therapies.
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New Hypertension Approach Hits Multiple Targets at Low Dose
