A recent study in eBioMedicine found a connection between SARS-CoV-2 infection and MDA5 autoimmunity, particularly in cases of interstitial lung disease (ILD) associated with dermatomyositis (DM). The study investigated the rise in MDA5-related disease during the COVID-19 pandemic and identified an increase in MDA5+ cases in the UK in 2021. The study proposed the term MIP-C to describe this phenomenon, which may be triggered by abnormal IFN responses. The study suggested that SARS-CoV-2 exposure or vaccination could induce autoimmune ILD through activation of the MDA5 protein. Further research is needed to validate these findings.
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COVID-19 linked to rise in autoimmune lung disease, study finds
