A study examined the benefits of hepatocellular carcinoma (HCC) screening in patients with cirrhosis or chronic hepatitis B virus (HBV) infection. The analysis showed that screening is associated with improved early-stage detection and survival benefits, even after adjusting for lead-time and length-time biases. Screening led to a higher rate of screen-detected HCC, with patients having a higher chance of early-stage disease and receiving curative treatment. Adjusting for length-time bias decreased survival estimates, but patients with screen-detected HCC still had lower mortality rates. The study suggests that HCC screening is important and associated with reduced mortality, despite potential biases and limitations of the study.
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HCC Screening of At-Risk Adults Improves Detection, Survival
