Researchers have identified specific brain pathways in the medial preoptic area that are responsible for premenstrual depression-like symptoms in mice. These GABAergic neurons, which regulate mood, become less active when estrogen levels drop, leading to depressive behaviors. By studying the impact of hormone fluctuations on mood in female mice and mapping the brain circuitry involved, scientists hope to develop targeted treatments for conditions such as postpartum depression, premenstrual dysphoric disorder, and menopause-related mood swings. Understanding these mechanisms may offer new possibilities for alleviating premenstrual mood disturbances and improving mental health in women.
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why am I depressed before my period?| Medical News Bulletin
