Research led by Mark Nelson and his team at UVM has revealed a new mechanism, E-Ca coupling, that integrates electrical and calcium signaling in brain capillaries to regulate blood flow. This process ensures precise delivery of blood to active neurons, crucial for maintaining brain function. By bridging electrical and calcium signals, E-Ca coupling allows for effective blood flow distribution across the brain, even in conditions like small vessel disease and Alzheimer’s. Understanding this mechanism provides insights into neurological conditions and potential treatments. The discovery highlights the importance of capillaries in managing blood flow and could lead to therapies that enhance brain health and function.
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UVM scientists discover new mechanism for blood flow regulation in the brain
