Prostate cancer hijacks the normal growth regulation program of the prostate by reprogramming the androgen receptor to promote cell growth. Researchers from Weill Cornell Medicine discovered that the androgen receptor, usually responsible for maintaining healthy prostate cells, is altered in cancer to drive tumor development. The study identified genes that normally suppress cell growth but are abandoned in cancer cells. Screening tissue samples from prostate cancer patients showed that tumors expressing the normal androgen receptor program had better patient outcomes. This research could lead to new diagnostic tests to guide treatment and potential therapies to reactivate the normal regulatory program in prostate cancer cells.
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Study unveils key mechanism behind prostate cancer’s uncontrolled growth
