Researchers at Baylor College of Medicine have gained insights into the molecular changes leading to Rett syndrome, a neurological disorder caused by mutations in the MeCP2 gene. Loss of MeCP2 in adulthood leads to dysregulation of hundreds of genes before any measurable neurological deficiencies are observed. The MeCP2 protein directs gene expression in neurons, and mutations disrupt this process, leading to Rett syndrome. By studying adult mice with MeCP2 deletion, researchers identified changes in gene expression related to neuronal function. Understanding these molecular events may help characterize the pathogenic cascade of Rett syndrome and identify potential therapeutic targets.
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Researchers discover molecular events leading to Rett syndrome
