Middle-aged adults with standing hypertension (SBP ≥ 140 mm Hg) have a higher risk for cardiovascular disease, while orthostatic increases in SBP do not show a significant association. A study from the ARIC cohort analyzed data from over 11,000 participants without CVD, finding that standing hypertension was linked to increased risks of heart disease, heart failure, stroke, fatal heart disease, and all-cause mortality. Orthostatic increases in SBP were not associated with significant CVD risks but showed an inverse association with heart failure. Combining orthostatic increases and standing hypertension into a single definition may be misleading, as they may have different risk factors and implications for CVD.
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Orthostatic Rises in SBP Not Tied to Increased CVD
