The discovery of the hormone leptin 30 years ago was initially hailed as a breakthrough in treating obesity. However, treatments mimicking leptin’s effects did not lead to significant weight loss. A new study has now shown that a molecule targeting specific neurons with both leptin and GLP-1 receptors can induce more weight loss in mice. This suggests a potential therapeutic strategy for combating obesity. Leptin alone may not be effective due to leptin resistance, but in combination with GLP-1 drugs, it could lead to more lasting weight loss. Further research is needed to determine the effectiveness of this approach in humans.
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New obesity drug combo uses hormone discovered 30 years ago
